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KMID : 0644120110240040010
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Journal of Oriental Gynecology
2011 Volume.24 No. 4 p.10 ~ p.19
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Effects of Kwibi-tang on Dermal Fibroblast
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Je Yun-Mo
Yoo Jeong-Eun
Choi Kyung-Hee
Lim Hyun-Jung
Yoo Dong-Youl
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Abstract
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Objectives: This study was performed to elucidate the effects of Kwibi-tang extract(KB) on dermal fibroblast.
Methods: To demonstrate the effects of KB on dermal fibroblast, we used human dermal fibroblast(F6) and UVB light(30 ) was used to damage to dermal fibroblast. we measured the nitrite production, LDH release in UVB-irradiated dermal fibroblast to elucidate the action-mechanism of KB. Also, we evaluated cell proliferation of dermal fibroblast and the amount of increased PICP, TIMP-1 in dermal fibroblast.
Results: 1. KB decreased the cell proliferation of F6 dermal fibroblast in concentration of 50 . 2. KB decreased the synthesis of PICP in concentration of 50 . 3. KB decreased the synthesis of TIMP-1 in concentration of 50 . 4. KB have no effect on the damage in UVB-irradiated F6 dermal fibroblast.
Conclusions: From the results, we concluded KB decreases the cell proliferation and collagen synthesis in dermal fibroblast. So we suggest that KB has the anti-hyperplasy of dermal fibroblast.
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KEYWORD
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Kwibi-tang Extract(KB), Dermal Fibroblast, Collagen, Anti-hyperplasy of Dermal Fibroblast
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